Genetic features of the glutathyon system of long livers of Carpathian region with comorbid pathology: arterial hypertension and osteoarthrosis

  • R. V. Kozoviy
  • L. Ye. Kovalchuk
  • H. M. Erstenyuk
DOI: https://doi.org/10.7124/FEEO.v23.1014

Abstract

Aim. To study the polymorphism of GSTM1, GSTT1 genes. To study the activity of enzymes encoding these genes in long-livers with arterial hypertension (AG) and osteoarthritis (OA). Methods. The determination of the frequency of polymorphous variants of gene deletions GSTT1 and GSTM1 and the activity of glutathione S-transferase (GST), glutathione reductase (GRD), glutathione peroxidase (GPO) was performed in long-livers, who were separated depending on the presence AG and OA. Results. In the group of patients with hypertension and OA genotype GSTM1«+»/GSTT1«+» met the GSTM1«+»/GSTT1«-» 3.0 times more often. The genotype GSTM1«-»/GSTT1«+» in comparison with GSTM1«-»/GSTT1«-» in this study group was 3.17 times. The study of GPO, GRD, and GST enzymes has shown a tendency to depend on its level from the health of long-livers. Conclusions. The advantage of genotypes with the active form of the gene GSTT1«+» was spotted among healthy long livers and patients with hypertension and OA. It indicates a better functioning of the antioxidant defense system. The activity of the enzymes of the glutathione system GPO, GRD, and GST was higher in healthy long-livers livers than in patients with comorbid pathology.

Keywords: glutathione system, longevity, arterial hypertension, osteoarthritis.

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