Розподіл алельних варіантів генів інгібіторів та активаторів ектопічної кальцифікації у пацієнтів із гострим коронарним синдромом

  • В. Ю. Гарбузова
  • О. А. Обухова
  • І. О. Розуменко
  • Є. І. Дубовик
  • Т. М. Олешко
  • Є. А. Гарбузова
  • Д. В. Швачко
  • О. В. Атаман
DOI: https://doi.org/10.7124/FEEO.v21.857

Анотація

Aim. The study of the distribution of polymorphic variants K121Q (gene ENPP1), T134967G (gene ANKH) and A69314G (gene TNAP) is in patients with acute coronary syndrome. Methods. Venous blood of 118 patients with ACS and 110 persons of control group were genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. Results. There is an association between acute coronary syndrome and polymorphic variants of genes TNAP (A69314G) and ANKH (T134967G). ACS risk in carriers of the minor allele of A69314G polymorphism to 2.2 times (P = 0.013; OR = 2.244), and for T134967G polymorphism to 1.9 times (P = 0.024; OR = 1.857) higher than homozygotes for the major allele. Conclusions. Allelic polymorphism gene activators and inhibitors of ectopic calcification is an important factor in hereditary susceptibility to sclerotic lesions of arteries and their complications.

Keywords: gene polymorphism, calcification, acute coronary syndrome.

Посилання

Schmermund A., Erbel R. Unstable Coronary Plaque and Its Relation to Coronary Calcium. Circulation. 2001. V. 104. Р. 1682–1687. doi.org/10.1161/hc3901.093339.

Talaeva T.V., Bratus' V.V. Sosudistaia kal'tsifikatsiia: real'nost' i gipotezy. Zdorov’ia Ukrainy. Kardiolohiia. Nauka – praktytsi. 2014, liutyy. P. 56–60. [in Russian]

Detrano R., Guerci A.D., Carr J.J., Bild D.E., Burke G., Folsom A.R., Liu K., Shea S., Szklo M., Bluemke D.A., O’Leary D.H., Tracy R., Watson K., Wong N.D., Kronmal R.A. Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups. The New England Journal of Medicine. 2008. V. 358. Р. 1336–1345. doi: 10.1056/NEJMoa072100.

Polonsky T.S., McClelland R.L., Jorgensen N.W., Bild D.E., Burke G.L., Guerci A.D., Greenland P. Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction. Journal of the American Medical Association. 2010. V. 303(16). Р. 1610–1616. doi: 10.1001/jama.2010.461.

Towler D.A. Inorganic Pyrophosphate. A Paracrine Regulator of Vascular Calcification and Smooth Muscle Phenotype. Arterioscler Thromb Vasc Biol. 2005. V. 25. Р. 651–654. doi: 10.1161/01.ATV.0000158943.79580.9d.

Clement T., Salone V., Charpentier B., Jouzeau J.Y., Bianchi A. Identification of new microRNAs targeting genes regulating the Pi/PPi balance in chondrocytes. Bio-medical materials and engineering. 2014. V. 24. P. 3–16. doi: 10.3233/BME-140969.

Huesa C., Houston D., Kiffer-Moreira T. The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization. Biochemistry and biophysics reports. 2015. V. 4. Р. 196–201. doi: 10.1016/j.bbrep.2015.09.013.

Moochhala S.H., Sayer J.A., Carr G., Simmons N.L. Renal calcium stones: insights from the control of bone mineralization. Exp. Physiol. 2007. V. 93(1). Р. 43–49. doi: 10.1113/expphysiol.2007.040790.

Ramaswamy J., Nam H.K., Ramaraju H., Hatch N.E., Kohn D.H. Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide. Biomaterials. 2015. V. 73. Р. 120–130. doi: 10.1016/j.boimaterials.2015.09.012.

Zweifler L.E., Patel M.K., Nociti F.H., Wimer H.F., Millán J.L., Somerman M.J., Foster B.L. Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis. International Journal of Oral Science. 2014. V. 1. Р. 1–15. doi: 10.1038/ijos.2014.62.

Du G., Zhan H., Ding D. Abnormal Mechanical Loading Induces Cartilage Degeneration by Accelerating Meniscus Hypertrophy and Mineralization After ACL Injuries In Vivo. Am. J. Sports Med. 2016. P. 652–663. doi: 10.1177/0363546515621285.

Moehlecke M., Kramer C.K., Leitão C.B., Krahe A.L., Balbosco I., Jobim de Azevedo M., Gross J.L., Canani Luis. H., ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients. Arq. Bras. Cardiol. 2010. V. 94(2). P. 157–161. dx.doi.org/10.1590/S0066-782X2010000200005.

Lazarevic G., Milojkovic M., Tasic I., Naiman S., Antic S., Stefanovic V. PC-1 (ENPP1) K121Q polymorphism in overweight and obese type 2 diabetic coronary heart disease patients. Acta Cardiologica. 2008. V. 63(3). P. 323–330. doi: 10.2143/AC.63.3.1020308.

Tasic I., Milojkovic M., Sunder-Plassmann R., Lazarevic G., Tasic N.M., Stefanovic V. The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease. Clinica Chimica Acta. 2007. V. 377. Р. 237–242. doi: 10.1016/j.cca.2006.10.003.

Stefanovic V., Antic S. Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus. Clinical Laboratory. 2004. V. 50. P. 271–278.

Shaker O.G., Ismail M.F. Association of genetic variants of MTHFR, ENPP1, and ADIPOQ with myocardial infarction in Egyptian patients. Cell Biochem. Biophys. 2014. V. 69. P. 265–274. doi: 10.1007/s12013-013-9794-2.

Endler G., Mannhalter C., Sunder-Plassmann H., Schillinger M., Klimesch A., Exner M., Kapiotis S., Meier S., Kunz F., Raiger E., Huber K., Wagner O., Sunder-Plassmann R. The K121Q polymorphism in the plasma cell membrane glycoprotein 1 gene predisposes to early myocardial infarction. J. Mol. Med. 2002. V. 80. P. 791–795. doi: 10.1007/s00109-002-0385-8.

Lee J.E., Choi Y.K., Seo H.A., Jeon J.H., Jeong J.Y., Moon S.S., Kim J.G., Kim B.W., Kim S.W., Min Yoo, Kim J.Y., Lee I.K. Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population. Diabetes research and clinical practice. 2010. V. 88. Р. 87–96. doi: 10.1016/j.diabres.2010.01.002.

Jeong D.J., Lee D.G., Kim H.J., Cho E.H., Kim S.W. ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus. Korean Diabetes J. 2010. V. 34. P. 320–326. doi: 10.4093/kdj.2010.34.5.320.

Eller P., Hochegger K., Feuchtner G.M., Zitt E., Tancevski I., Ritsch A., Kronenberg F., Rosenkranz A.R., Patsch J.R., Mayer G. Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure. Nephrol. Dial. Transplant. 2008. V. 23. Р. 321–327. doi: 10.1093/ndt/gfm566.