Integration of modern genetic knowledge in the course “Genome organization”

Keywords: structural and functional organization of the genome, genomic information, genetic technologies, systemic integrated knowledge

Abstract

Aim. To summarize the experience of teaching the course «Organization of the Genome» to substantiate the need to integrate the latest scientific data into the educational process and form a systematized complex of knowledge about genomes and molecular genetic technologies. Methods. Optimization of teaching methods with the content load of the course and the use of practically oriented problem-search tasks. Results. The course structure provides for the gradual formation and deepening of the system of knowledge about the structure, polymorphism, functioning and regulation of genetic systems. Special attention is given to the consideration of modern molecular genetic and information technologies of genomic analysis as a future methodological base for solving current applied problems. Conclusions. Formation of a network of modern knowledge among students regarding molecular genetic systems, the features of their functioning and mechanisms of regulation is an urgent need of today. The maximally integrated perception of the genomic component of biological systems is a prerequisite for the effective application of the acquired knowledge for genetic manipulations of various levels: from diagnostics to correction and editing.

References

Piskun R. P., Shkarupa V. M., Grynchak N. M. et al. The modern concept of teaching genetics at a medical higher educational institution. Factors in experimental evolution of organisms. 2019. Vol. 25. P. 368–372. https://doi.org/10.7124/FEEO.v25.1193.

Hedzur T. I., Vakerych M. M., Kolesnyk A. V. Methodological approaches to teaching genetics in higher education institutions of Ukraine. Scientific innovations and advanced technologies. 2024. Vol. 2 (30). P. 1054–1065. https://doi.org/10.52058/2786-5274-2024-2(30)-1054-1065.

Gyl M. I., Smetana O. Yu., Yulevych O. I. et al. Molecular genetics and genome research technologies: a textbook / ed.: M. I. Gyl. Mykolaiv : MNAU, 2014. 280 p. [in Ukrainian]

Paro R., Grossniklaus U., Santoro R., Wutz A. Introduction to epigenetics. Switzerland : Springer Nature Switzerland AG, 2023. 219 р. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/36315658/.

Gasynets Ya. S., Shchubelka Kh. M., Wolfsberger V. V. et al. Introduction to genomic biology: a teaching and methodological manual. Uzhhorod : Publishing house of UzhNU “Hoverla”, 2023. 42 p. [in Ukrainian]

Diniz W. J, Canduri F. Bioinformatics: an overview and its applications: review-article. Genetics and Molecular Research. 2017. Mar 15. Vol. 16 (1). doi: 10.4238/gmr16019645.

Rajagopa K. Recombinant DNA technology and genetic engineering. New Delhi : Tata McGraw Hill Education Private Limited. 2012. 342 p.

Tofazzal Islam M., Kutubuddin Ali Molla CRISPR-Cas methods: Springer protocols handbooks. Volume 2. Springer Science+Business Media, LLC, part of Springer Nature. 2022. 399 р. Retrieved from: https://dokumen.pub/crispr-cas-methods-volume-2-springer-protocols-handbooks-1071616560-9781071616567.html.

Rudyshyn S. D. Plant biotechnology: a textbook. Sumy : PVKP "Korpunkt", 2024. 199 p. [in Ukrainian]