Hereditary gluten enteropathy in irish setters: evaluation of external parameters, clinical symptoms and fatal risks

Keywords: Irish Setter, gluten enteropathy, diet, heredity, exterior, fatal risks

Abstract

Aim. Determine the features of appearance, clinical signs and fatal risks in Irish setters with hereditary gluten enteropathy. Methods. The methods used were observation, eye examination, clinical examination, autopsy, histological. Results. It has been established that in hereditary gluten enteropathy in Irish setters there are violations of the parameters of appearance, weak ability to train, fulminant and chronic forms of damage to the intestinal wall by type of enteropathy, anaphylactic reactions and cerebral disorders. In the dead setters, the causes of death were hypovolemic shock due to intestinal bleeding and combined critical injuries of the brain, heart and lungs. Conclusions. Violations of the parameters of appearance in setters with hereditary gluten enteropathy led to their unsuitability for hunting. Dietary therapy with the exclusion of feed containing cereals was effective in stabilizing the condition of sick setters. Setters with hereditary gluten enteropathy are at risk of developing fatal cardiovascular, pulmonary, and cerebral insufficiency. The validity of the spread of hereditary gluten enteropathy in Irish setters depends on the accounting of the results of multi-year studies by a multidisciplinary group of specialists.

References

Taraghikhah N., Ashtari S., Asri N., Shahbazkhani В., Al-Dulaimi D., Rostami-Nejad М., Rezaei-Tavirani М., Reza Razzaghi М., Reza Zalі М. An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC Gastroenterol. 2020. Vol. 20. P. 258. doi: 10.1186/s12876-020-01390-0.

Volta U., Caio G., Tovoli F., De Giorgio R. Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness. Cell Mol Immunol. 2013. Vol. 10 (5). P. 383–392. doi: 10.1038/cmi.2013.28.

Lindfors K., Ciacci C., Kurppa K., Lundin K. E. A., Makharia G. K., Mearin M. L., Murray J. A., Verdu E. F., Kaukinen K. Coeliac disease. Nat Rev Dis Primers. 2019. Vol. 10. S. 5 (1). P. 3. doi: 10.1038/s41572-018-0054-z.

Bascuñán K. A., Roncoroni L., Branchi F., Doneda L., Scricciolo А., Ferretti F., Araya М., Elli L. The 5 Ws of a gluten challenge for gluten-related disorders. Nutr Rev. 2018. Vol. 76 (2). P. 79–87. doi: 10.1093/nutrit/nux068.

Liakhovych L. M., Kostiuk I. O. Swine celiac disease: pathogenesis, clinical and pathological and anatomic typization. Problems of animal engineering and veterinary medicine. 2017. Vol. 35 (1). P. 161–165. [in Ukrainian]

Liakhovych L. M. Edema disease of swine: differentiation of clinical variants and terminal pathologies. Veterinary biotechnology. 2018. Vol. 32 (2). Р. 335–341. [in Ukrainian]

Khokhlov A. M., Honcharova І. І., Fediaieva A. S., Shevchenko О. В. Phylogenetic processes in dog domestication and breeding. Factors in the experimental evolution of organisms. 2023. Vol. 35. P. 79–84. doi: 10.7124/FEEO.v33.1570. [in Ukrainian]

Cynology: keeping, feeding, training of dogs : a textbook / V. A. Burlaka [et al]; SAEU. 2023. 412 p. [in Ukrainian]

Biagi F., Maimaris S., Vecchiato C., Costetti М., Biagi G. Gluten-sensitive enteropathy of the Irish Setter and similarities with human celiac disease. Minerva Gastroenterol Dietol. 2020. Vol. 66 (2). P. 151–156. doi: 10.23736/S1121-421X.19.02648-5.

Lowrie M., Hadjivassiliou M., Sanders D. S., Garden O. A. A presumptive case of gluten sensitivity in a border terrier: a multi-system disorder? Vet Rec. 2016. Vol. 179 (22). P. 573. doi: 10.1136/vr.103910.

Horalskyi L. P., Khomych V. T., Kononskyi O. I. Histological techniques and methods of morphological studies in normal and pathological conditions. Zhytomyr : Polissia. 2015. 286 p. [in Ukrainian]

Honcharova І. І. Features of breeding in dog. Scientia. 2023. P. 52–56. doi: 10.36074/scientia-27.10.2023. [in Ukrainian]

Kolb N., Alf V., Cappello R., Rosati M., Matiasek K. Novel association of gluten sensitivity with immune-mediated neuromuscular syndrome in a dog. Neuromuscular Disorders. 2022. Vol. 32 (11–12). P. 903–907. doi: 10.1016/j.nmd.2022.06.007.

Rodrigo L., Beteta-Gorriti V., Alvarez N., Gómez de Castro C., de Dios A., Palacios L. Cutaneous and mucosal manifestations associated with celiac disease. Nutrients. 2018. Vol. 10. Р. 800. doi: 10.3390/nu10070800.

Matsenko O., Maslak Yu., Kusch L., Shchepetilnikov Yu., Ilina O. Effectiveness of the use of the veterinary drug triosan (cream) in the complex therapy of dogs for atopic dermatitis. SWorldJournal. 18 (2). P. 9–17. doi: 10.30888/2663-5712.2023-18-02-040.