Influence of taurine on phenotype expression of muscular dystrophy in Drosophila melanogaster

  • T. K. Orlov
  • S. M. Gorbulinska
  • H. M. Klepach
  • М. А. Kryzhanovska
  • N. Ia. Holub
DOI: https://doi.org/10.7124/FEEO.v27.1327

Abstract

Aim. To investigate the effect of 0.1% taurine on the manifestation of muscular dystrophy in Drosophila melanogaster mutants under both larval and adult feeding. Methods. Larval and adult feeding of 0.1 % taurine, construction of survival curves and study of moving activity, making thorax muscles histological preparations. Results. It has been shown the increasing of life span indexes (on 46-75%). moving activity (on 50-75%), decreasing of fatigue rates, and reducing of muscle damages (on 6-20%) in Drosophila dystrophy mutants under the influence of 0.1% taurine. Conclusions. The results indicate a positive effect of 0.1% taurine as a stimulant, antioxidant, myoprotector, blocker of fatigue processes in dystrophin mutants. However, following further studies on vertebrates, taurine may be recommended as a therapeutic agent in the treatment of Duchenne muscular dystrophy.

Keywords: Drosophila, dystrophin, miodystrophy, taurine.

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