Distribution of allelic variants of genes inhibitors and activators ectopic calcification in patients with acute coronary syndrome

  • V. Yu. Harbuzova
  • O. A. Obukhova
  • I. O. Rozumenko
  • Ye. I. Dubovyk
  • T. M. Oleshko
  • Ye. A. Harbuzova
  • D. V. Shvachko
  • O. V. Ataman


Aim. The study of the distribution of polymorphic variants K121Q (gene ENPP1), T134967G (gene ANKH) and A69314G (gene TNAP) is in patients with acute coronary syndrome. Methods. Venous blood of 118 patients with ACS and 110 persons of control group were genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. Results. There is an association between acute coronary syndrome and polymorphic variants of genes TNAP (A69314G) and ANKH (T134967G). ACS risk in carriers of the minor allele of A69314G polymorphism to 2.2 times (P = 0.013; OR = 2.244), and for T134967G polymorphism to 1.9 times (P = 0.024; OR = 1.857) higher than homozygotes for the major allele. Conclusions. Allelic polymorphism gene activators and inhibitors of ectopic calcification is an important factor in hereditary susceptibility to sclerotic lesions of arteries and their complications.

Keywords: gene polymorphism, calcification, acute coronary syndrome.


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