The action of extracts of oyster mushrooms and plant collection on survival and the average life expectancy of irradiated mice

E. N. Shamilov, A. S. Abdullaev, I. V. Azizov

Анотація


Aim. The aim of this work was to evaluate the effect of extracts obtained from oyster mushroom (Pleurotus ostreatus) and vegetable collection, consisting of marigold flowers (Calendula officinalis), St. John's wort (Hypericum perforatum) and yarrow (Achillea millefolium) on survival and the average life expectancy of irradiated mice. Methods. Medicinal plants included in the collection and of oyster mushrooms were dried, and were obtained the extract of water-alcohol mixture. Extracts vnutribryushinno was administered to mice at a concentration of 250 mg/kg 30 min before irradiation at a dose of 9 Gy. Results. It is found that the introduction of the extract of the oyster mushroom there is a significant increase of life expectancy of lethally irradiated animals, although the survival rate after 30 days is slightly inferior to that of the introduction of the radioprotector of the standard. In the case of a complex extract also increase the duration of life of irradiated animals, however, the percentage of survival after the end of the experiment – 30 days – less oyster extract. Conclusions. The data obtained indicate the prospects of using oyster extract separately and in com-plex with extracts of calendula, St. John's wort and yarrow in the development of pharmaceutical compositions intended for the prevention of local radiation injuries.

Keywords: mouse, survival, irradiation, extract.


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