The action of extracts of oyster mushrooms and plant collection on survival and the average life expectancy of irradiated mice

  • E. N. Shamilov
  • A. S. Abdullaev
  • I. V. Azizov


Aim. The aim of this work was to evaluate the effect of extracts obtained from oyster mushroom (Pleurotus ostreatus) and vegetable collection, consisting of marigold flowers (Calendula officinalis), St. John's wort (Hypericum perforatum) and yarrow (Achillea millefolium) on survival and the average life expectancy of irradiated mice. Methods. Medicinal plants included in the collection and of oyster mushrooms were dried, and were obtained the extract of water-alcohol mixture. Extracts vnutribryushinno was administered to mice at a concentration of 250 mg/kg 30 min before irradiation at a dose of 9 Gy. Results. It is found that the introduction of the extract of the oyster mushroom there is a significant increase of life expectancy of lethally irradiated animals, although the survival rate after 30 days is slightly inferior to that of the introduction of the radioprotector of the standard. In the case of a complex extract also increase the duration of life of irradiated animals, however, the percentage of survival after the end of the experiment – 30 days – less oyster extract. Conclusions. The data obtained indicate the prospects of using oyster extract separately and in com-plex with extracts of calendula, St. John's wort and yarrow in the development of pharmaceutical compositions intended for the prevention of local radiation injuries.

Keywords: mouse, survival, irradiation, extract.


Maksiutina N.P., Komissarenko N.F., Prokopenko A.P. etc.. Ed. Maksiutina N.P. Kyiv: Health, 1985. 280 p.

Nikolaev S.M., Ledneva I.P., Samylina I.A., Ivashchenko N. In. Study of spasmolytic and diuretic activity of the herb. Reserves of improvement of drug provision of the population of the Russian Federation: proc. Dokl. Vladimir. 1991. P. 21–22.

Aliev R.K., Prilipko L.I., Damirov I.A. Medicinal plants of Azerbaijan. Directory. Baku: Azerbaijan state publishing house, 1972.

Shamilov E.N., Abdullayev I.A. Rzayeva A., Azizov I.V. Influence of iron complexes on the formation of photosynthetic apparatus and yield genetic changes in gamma irradiated wheat seeds. Visnyk of Dnipropetrovsk University. Biology. Medecine. 2010. V. 18(2). P. 90–95.

Mamedov N.A., Craker L.E., Shamilov E.N., Rzayev A.A., Abdullaev A.S., Rzayeva I.A., Gasimova N.I., Guliev G.N. Radioprotective Activity of Some Medicinal Plant Extracts. Science and Horticulture for People: abstracts of 28th International Horticultural Congress, International Society for Horticultural Science ISHS, (August 22–27, 2010). Lisboa, Lisbon Congress Centre, 2010. V. 1. P. 84.

Kasumov F.Yu., Shamilov E.N., Abdullayev A.S., Gasimov N., Kuliev G.N. Study of the component composition of the extract of saffron (Crocus sativus L.) and its radioprotective action. Russia. Supplement to the magazine ‘Traditional medicine’. 2010. No. 3 (22). P. 140–146.

Shamilov E.N., Abdullayev A.S., Akhmedov I.D., Azizov I.V. Study of radioprotective properties polymermodified extract of Hypericum perforatum L.. International Conference ‘Radiobiological and radioecological aspects of the Chernobyl disaster’. The international Association of Academies of Sciences, national Academy of Sciences of Ukraine and Russia. Abstracts. Slavutich, 2011. P. 149.

Shamilov E.N., Abdullayev A.S., Rzayeva I.A. Radioprotective activity of the extract of Achillea millefolium L.. Min. of education and science of Ukraine, Radiobiological total TSS of Ukraine, Materials of international conference “Radioprotectors, effective under the action of chronic irradiation in small doses”: abstracts, (16–20 June 2008). Nikolaev, 2008. P. 86–87.

Shamilov E.N., Rzayev A.A., Abdullayev A.S., Gasimov N., Kuliev G.N., Mamedrzaev E.T., Gaziyev A.G., Azizov I.V. Cytogenetic changes in irradiated rats under the influence of plant bio-complexes. Proceedings of the Georgian Academy of Sciences, Biological Series A. Tbilisi, 2009. V. 35. P. 393–401.

Shamilov E.N., Abdullayev A.S., Azizov I.V. The Study of radioprotective properties of some plant extracts. The materials of the XX anniversary international Symposium “Non-traditional crop. Selection and genetics. Protection of ionosphere. Eniology. Ecology and health” 4–11 September 2011. Alushta, Simferopol, 2011. P. 509–514.

Shamilov E.N., Abdullaev A.S., Gaziyev A.G., Sadigova G.A., Azizov I.V. Some parameters of the blood of irradiated rats against the background of the introductions of plant extracts. 10th Low Rad Konference 2011 “The effects of low very low doses of ionizing radiation on human health and biotopes” December 5–7, 2011. Kyiv, 2011. P. 90.

Mamedov N.A., Rzayev A.A., Shamilov E.N., Abdullaev A.S., Craker L.E. Radioprotective activity of some medicinal plant extracts. Acta Hort. (ISHS). 2011. V. 925. P. 315–320. Retrieved from:

Shamilov E.N., Abdullayev A.S., Guliyev G.N., Gasimov N.I., Azizov I.V. Study of radioprotective effect of Crocus sativus L. extract. Visnik ukrains'kogo tovaristva genetikiv i selekcioneriv. 2012. V. 10(1). P. 95–99.

Azizov I.V., Shamilov E.N., Abdullaev A.S. Influence of a mixture of extracts derived from plants on blood elements and behavioral response of irradiated rats. IX International Interdisciplinary Congress Neuroscience for medicine and psychology. Sudak, Crimea, Ukraine, 3–13 june 2013. P. 45.

Shamilov E.N., Abdullaev A.S., Azizov I.V. Comparative study of the radioprotective properties of extracts of calendula, chamomile and milfoil. Journal of Radiation Researches. Baku, 2014. V. 1(1). P. 72–75.

Shamilov E. Comparative study of the impact of phytocomposition extract on some blood characteristics of irradiated rats. International Journal of Pharmaceutical Science and Health Care, May–June 2015. 2015. V. 3(5). P. 118–121.