Celiac disease HLA-markers in men as a genetic component of idiopathic reproductive losses

  • O. I. Terpylyak State Institution «Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0001-6274-8362
  • D. V. Zastavna State Institution «Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-3858-7180
  • K. O. Sosnina State Institution «Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0003-4527-2010
  • O. L. Filenko Institute of Food Biotechnology and Genomics NAS of Ukraine, Ukraine, 04123, Kyiv, Baidy Vyshnevetskoho str., 2A https://orcid.org/0009-0002-7160-2546
DOI: https://doi.org/10.7124/FEEO.v35.1660
Keywords: idiopathic recurrent pregnancy loss, celiac desease, HLA genotyping

Abstract

Aim. To investigate distribution of HLA-DQ2.5 (HLA-DQA1*05:01 + HLA-DQB1*02) and HLA-DQ8 (HLA-DQB1*03:02) genotypes among men from couples with idiopathic reproductive losses. Methods. PCR-SSP (polymerase chain reaction with sequence-specific primers). Results. An association of idiopathic reproductive losses with the carrier of DQ2.5 – the celiac disease predisposition genotype in men (χ2=6.79, P<0.01) was established. The OR indicator (odds ratio) proves that the risk of idiopathic reproductive losses in the presence of the DQ2.5 genotype in men increases 5 times. The results of the work indicate an equal contribution of men with the celiac genotype as a possible cause of reproductive losses of unknown origin. Conclusions. The study of HLA-markers of susceptibility to celiac disease in couples (both in women and in men) with reproductive losses of unknown origin is extremely important and of great practical importance for the purpose of preconceptional prevention of such losses.

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