The role of folate metabolism genome in the formation of triiodothyronine in children living in areas affected by the Chernobyl nuclear power plant accident

  • Yu. I. Bandazhevsky
  • N. F. Dubovaya
DOI: https://doi.org/10.7124/FEEO.v24.1101

Abstract

Aim. Aim of this study was to determine the role of the genome of folate metabolism in the formation of triiodothyronine in children living in areas affected by the Chernobyl nuclear power plant accident. Methods. Immunochemical, mathematical and statistical. Results. The proportion of cases of elevated blood levels of triiodothyronine is statistically significantly higher in the group of children who are carriers of the G risk allele of the MTR:А2756G genetic polymorphism associated with the В12-dependent methionine synthase enzyme than in the group of children who have no this allele (MTR:2756 A/A genotype). The formation of triiodothyronine is associated with the metabolic conversion of homocysteine involving vitamin В6 as a cofactor of cystathionine β-synthase. Conclusions. The cause of thyrotoxic effects with damage to the cardiovascular system may lie in high levels of homocysteine occurring due to impaired functioning of В12-dependent methionine synthase.

Keywords: folate metabolism, triiodothyronine, genetic polymorphisms, radiation-contaminated areas.

References

Koh N.F., Sleuhina A.A., Livshits G.I. Folatnii tsikl: obzor i prakticheskie rekomendatsii po interpretatsii geneticheskih testov. Meditsinskaya genetika. 2015. No 11. P. 3–8. [in Russian]

Zagal’nodozimetrichna pasportizatsіya ta rezul’tati LVL-monіtoringu v naselenih punktah Ukraїni, yakі zaznali radіoaktivnogo zabrudnennya pіslya Chornobil’s’koї katastrofi. Danі za 2011 r. Zbіrka 14. K.: MOZ Ukraїni, NAMNU Ukraїni, MNS Ukraїni, DAZV, DU "NNTSRM NAMN Ukraїni", ND ІRZ ATN Ukraїni, 2012. 99 p. [in Ukrainian]

25 rokіv Chornobil’s’koї katastrofi. Bezpeka maibutn’ogo: Natsіonal’na dopovіd’ Ukraini. K.: KІM, 2011. 356 p. [in Ukrainian]

Mamenko M.E. Ioddefitsitni zahvoryuvannya v ditei na shodi Ukraini: cuchasnii stan problemi ta shlyahi virishennya. Mezhdunarodnii endokrinologicheskii zhurnal. 2008. V. 3, No 15. P. 16–21. [in Ukrainian]

Bandazhevsky Yu.I., Dubova N.F. The role of genome of folate metabolism in the occurrence of hyperhomocysteinemia in children from the areas affected by the Chernobyl nuclear power plant accident. Scientific and practical collection «Chernobyl: ecology and health». Issue 6. Ivankov: PI Coordination and Analytical Center «Ecology and health», Dnipro: Serednyak Т.К., 2017. P. 27–35.

Bandazhevsky Yu.I., Dubova N.F. The genotype of the folate cycle and the correlation between metabolic rates in children living in areas affected by the Chernobyl nuclear power plant. Scientific and practical collection «Chernobyl: ecology and health». Issue 7. Ivankov: PI Coordination and Analytical Center «Ecology and health», Dnipro: Serednyak Т.К., 2018. P. 18–29.

Bandazhevsky Yu.I., Dubova N.F. Correlation relations between vitamins B6, B9 and B12 in different genotypes of the folate cycle, in children from the area affected by the accident at the Chernobyl nuclear power plant. Scientific and practical collection «Chernobyl: ecology and health». Issue 7. Ivankov: PI Coordination and Analytical Center «Ecology and health», Dnipro: Serednyak Т.К., 2018. P. 29–38.

Biondi B., Palmieri Emiliano A., Lombardi Gaetano, Fazio Serafino Effects of Thyroid Hormone on Cardiac Function: The Relative Importance of Heart Rate, Loading Conditions, and Myocardial Contractility in the Regulation of Cardiac Performance in Human Hyperthyroidism. J. Clin. Endocrinol. Metab. 2002. Vol. 87 (3). P. 968–974.

Schitovidnaya zheleza. Fundamental’nie aspekti / Pod red. prof. A.I. Kubarko i prof. S. Yamashita. Minsk – Nagasaki, 1998. 368 p. [in Russian]