Studying the radioprotective properties of some phytoextracts from Azerbaijan pharmaceutical flora
Aim. The aim of this work is to evaluate the radioprotective properties of the extract from the flowers of calendula officinalis (Calendula officinalis L.) alone and phytoextracts (CDY) consisting of calendula officinalis (Calendula officinalis), dandelion officinalis (Taráxacum officinále) and yarrow (Achillea millefolium) obtained from medicinal flora of Azerbaijan. Methods. The medicinal plants included in the collection were dried and the extract obtained in a water-alcohol mixture. The extracts were injected intraperitoneally in mice at a concentration of 300 mg / kg 30 min before irradiation at a dose of 9 Gy. Results. It was found out that the extract of calendula possesses radioprotective activity (55%), somewhat inferior to the activity of the protector-standard of cystamine (80%), and phytoextracts (CDY) decreasing the lethal effect of ionizing radiation, has radioprotective activity (62%) and increases survival and life expectancy lethally irradiated mice more than the extract of calendula (55%) and less cystamine (80%). Conclusions. The data obtained by us testify to the prospects of using the extract of calendula separately and in a complex of extracts of dandelion and yarrow in the development of medicinal compositions intended for preventive purposes and in order to prevent local radiation injuries.
Keywords: mice, survival, irradiation, extract, cystamine.
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