Study of a new group of membrane-acting tissue-specific homeostatic bioregulators

  • V. P. Yamskova
  • M. S. Krasnov
  • E. Yu. Rybakova
  • O. G. Koulikova
  • A. P. Il’ina
  • I. A. Yamskov


Aim. The study of a new group of tissue-specific homeostatic membranotropic bioregulators isolated from various tissues of animals and plants. Methods. Physical and chemical properties of a new bioregulator have been studied by isoelectric focusing, reversed-phase HPLC, polyacrylamide gel electrophoresis, circular dichroism, MALDI-TOF mass spectrometry, laser dynamic light scattering, atomic force microscopy. Results. The bioregulators of this group consist of a biologically active peptides and proteins related to the superfamily of serum albumin, which modulate the activity of these peptides. These components interact through the mechanism of carbohydrate-protein interactions, and albumin function as lectins that recognize carbohydrate component peptides. Conclusions. Our results indicate that the cells are present on the surface of certain macromolecular structures involved in cell adhesion and in the regulation of basic biological processes.

Key words: bioregulators, cell adhesion, serum albumins.