Adhesion proteins are able to controle the proliferation and size of neonatal cardiomoycytes in Mus musculus

  • V. V. Balatskyi Institute of Molecular Biology and Genetics of Natl. Acad. Sci. of Ukraine, Ukraine, 03143, Kyiv, Akad. Zabolotnogo str., 150
  • L. L. Macewicz Institute of Molecular Biology and Genetics of Natl. Acad. Sci. of Ukraine, Ukraine, 03143, Kyiv, Akad. Zabolotnogo str., 150
  • T. P. Ruban Institute of Molecular Biology and Genetics of Natl. Acad. Sci. of Ukraine, Ukraine, 03143, Kyiv, Akad. Zabolotnogo str., 150
  • O. O. Piven Institute of Molecular Biology and Genetics of Natl. Acad. Sci. of Ukraine, Ukraine, 03143, Kyiv, Akad. Zabolotnogo str., 150
DOI: https://doi.org/10.7124/visnyk.utgis.16.1.897

Abstract

Aim. In our present work, we have analyzed the influence of adhesion proteins — catenins on the proliferation of neonatal cardiomyocytes, under there cardiac-specific knockout. Methods. The studies were conducted using mice with a conditional knockout of the β-catenin gene (β-catflox/flox); αE-catenin (αE-catflox/flox) and transgenic animals which express the Crerecombinase under the control of the heavy chain promoter of α-myosin ((αMHC) -Cre). Results. The cardiac ablation of the β-catenin gene results in lower cell proliferation and decreased myocardial size, whereas the knockout of αE-catenin, increased proliferation as well as the size of the newborn heart. Conclusions. Intercellular adhesion genes — β-catenin and αE-catenins have not only an important structural function in maintaining of the myocardium tissue structure, but also involved in controlling of the proliferation, size of neonatal cardiomyocytes and newborn heart.
Keywords: β-catenin, αE-catenin, cardiomyocytes, proliferation.

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