Plant clones of Deschampsia as a source phenolic compounds with antitumor properties

  • О. О. Поронник Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine, 03680, Kyiv, Acad. Zabolotnoho str., 150
  • А. В. Кузьменко National Aviation University Ukraine, 03680, Kyiv, Komarova ave., 1
  • А. В. Воловик Taras Shevchenko National University of Kyiv, NSC "Institute of Biology" Ukraine, 04033, Kyiv, Volodymyrska str., 64
  • Л. В. Швачко Taras Shevchenko National University of Kyiv, NSC "Institute of Biology" Ukraine, 04033, Kyiv, Volodymyrska str., 64
  • О. В. Войцехівська Taras Shevchenko National University of Kyiv, NSC "Institute of Biology" Ukraine, 04033, Kyiv, Volodymyrska str., 64
  • Г. Ю. Мирюта Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine, 03680, Kyiv, Acad. Zabolotnoho str., 150
  • Т. А. Рубан Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine, 03680, Kyiv, Acad. Zabolotnoho str., 150
  • І. Ю. Парнікоза Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine, 03680, Kyiv, Acad. Zabolotnoho str., 150
  • В. А. Кунах Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine, 03680, Kyiv, Acad. Zabolotnoho str., 150

Abstract

Aim was the comparative study of phenolic compounds content and antitumor activity of biomass extracts of  Deschampsia species plants micropropagated in vitro. Methods. Content of total phenols (by gallic acid) and flavonoids (by rutin) was determined in dry plant biomass. Antitumor activity of plant extracts was determined by the test CellTiter 96® with the use of the chronic myelogenous leukemia cell line K562. Plant biomass and extracts from micropropagated D. antarctica plants grown from seeds collected from the Argentine Islands region of Maritime Antarctic and D. caespitosa grown from seeds collected from Vyshgorod firing range near Kyiv (Ukraine) were investigated. Results. Antitumor activity of the extracts from micropropagated Deschampsia species plants was found to be directly dependent on total phenolic content. Conclusion. In vitro culture of Deschampsia species plants are promising for the development of biotechnology for the production of anticancer drugs.

Key words: hairgrass, D. antarctica, D. caespitosa, flavonoids, antitumor activity.