Evolution of the MGMT gene in primates: from structure to mobile genetic elements
Abstract
The article collects data on the evolution of the reparative MGMT gene in primates and traces the evolutionary fate of a number of mobile genetic elements (MGEs). It was concluded that the evolution of the MGMT gene in primates underwent various changes from acquisition to loss of exon/intron sequences. As for primate-specific MGEs, they have a different evolutionary history and path - from the formation of species/genus-specific sequences to deletional degradation and can be components not only of intronic or exonic sequences, but also components of exons in the form of fragmented sequences and not be identified as MGEs.
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