Dynamics of activity of energy supply enzymes of rat brain against the background of exposure to stress factors
Abstract
Aim. The aim of this work was to give a review of own studies of dynamics of the activity of energy metabolism enzymes in the brain during postnatal ontogenesis which characterizes the functional relations within the analysers, the destruction of their functions and the impact of adverse environmental factors on the body as well. Methods. The methods for the determination of the activity of energy metabolism enzymes in the brain of animals under the impact of adverse environmental factors and dysfunction of the analysers have been used. Results. It has been stated that the enzyme activity is regionally different in the tissues and sub cellular fractions of the brain depending on the animal species and the degree of the intensity of the stress factors, age and sex of the animal, circadian rhythms, season andmoreover, the resulting changes in the enzyme activity in most casesare irreversible. Conclusions. The data allow the dynamics of the activity of the energy supply enzymes to be considered as a determinant of cell reaction in response to exposure to adverse environmental factors and disturbance of sensory impulsation, which results in temporary increasing in the protection of intracellular energy metabolism through the development of an adaptive brain response.
Key words: ontogenesis, brain, analysers, enzymes, environmental factors.
References
Askerov F. B., Rashidova A. M., Movsum-zade K. M. i dr. Nekotorye osobennosti mehanizma energoobespecheniya mozga na modeli bezbelkovogo pitaniya krys godovalogo vozrasta. Izvestiya AN Azerbaydzhana, Baku. 2006. 3–4. P. 111–121.
Baba-zade S. N. Belkovoe golodanie i energeticheskiy obmen v golovnom mozge belyh krys. Sb. trudov Instituta Fiziologii im. A. I. Karaeva NANA, Baku. 2004. Vol. XXII. P. 203–212.
Baba-zade S. N., Rashidova A. M., Abieva E. Sh., Mamedhanova V. V. Polovye otlichiya aktivnosti nekotoryh fermentov metabolizma glyukozy v usloviyah gipoksii // Sb. trudov Instituta Fiziologii im. A. I. Karaeva NANA. 2010. Vol. XXVIII. P. 146–152.
Bankov V. I. Elektromagnitnye informatsionnye protsessy biosfery. Ekaterinburg, UGMA, 2004. 208 p.
Vulfson E. N., Kozlov I. A., Murataliev M. B. Mehanizm funktsionirovaniya mitohondrialnoy F1-ATF-azy. Kooperativnost v svyazyvanii ADF i neorganicheskogo fosfata v kataliticheskom tsentre F1-ATF-azy. Biol. membr. 1985. Vol. 2. P. 160–169.
Grubinko V. V., Leus Yu. M, Arsok O. M. Perekisnoe okislenie lipidov v tkanyah karpa pri deystvii ammiaka. Gidrobiologicheskiy zhurnal. 1996. 32.4. P. 52–57.
Dzhabbarov M. I. Fiziologo-biohimicheskaya otsenka sostoyaniya osetrovyh ryb v usloviyah zagryazneniya vody neftyu i nefteproduktami. In. «Patologicheskie protsessy i metody ih korrektsii», Baku, 1998, p. 138.
Efremovich N. V. i dr. Vydelenie i pervichnaya harakteristika dvuh form ne-organicheskoy pirofosfatazy iz mitohondriy serdechnoy myshtsy byka. Biohimiya. 1980. Vol. 45(6). P. 1033–1039.
Eschenko N. D. Energeticheskiy obmen v golovnom mozge. In: Biohimiya mozga. Izd-vo S.-P. Univers. 1999. P. 124–169.
Zhuravin I. A., Tumanova N. L., Vasilev D. S. Izmenenie adaptivnyh mehanizmov mozga v ontogeneze krys, perenesshih prenatalnuyu gipoksiyu. Doklady Akademii nauk. 2009. Vol. 425(1). P. 123–125.
Kassil V. G., Otellin V. A., Hozhay L. I., Kostkin V. B. Kriticheskie periody razvitiya golovnogo mozga. Ros. fiziol. zh. 2000. Vol. 86(11). P. 1418–1425.
Kurbanova B. R., Rashidova A. M., Askerov F. B. Izmenenie soderzhaniya obschego belka v tkanyah I subkletochnyh fraktsiyah razlichnyh oblastey kory golovnogo mozga i gipotalamusa 3-mesyachnyh krys pri belkovom golodanii. Sb. trudov Instituta Fiziologii im. A. I. Karaeva NANA, materialy III s’ezda ob-va fiziologov Azerbaydzhana. Baku. 2005. P. 355–365.
Mehtiev A. A., Rashidova A. M., Muslimov I. A. Ingibirovanie potrebleniya morfina antitel amikserotonin moduliruemomu antikonsolidatsionnomu belkuv modeli samovvedeniyau krys. Zh. Vysshey nervnoy deyatelnosti. 2014. Vol. 64(2). P. 231–239.
Metsler D. Biohimiya. Moskva, 1980. Vol. II. P. 461–463.
Miheeva I. G., Ryukert E. N., Brusov O. S. i dr. Soderzhanie serotonina v syvorotke krovi no vorozhdennyh detey s gipoksicheski-ishemicheskim porazheniem TsNS. Pediatriya. 2008. Vol. 87(1). P. 40–44.
Movsum-zade K. M., Rashidova A. M., Panahova H. G., Kurbanova B. R. Belkovoe golodanie i aktivnost laktatdegidrogenazy v golovnom mozge krys. Tr. In-ta Fiziologii im A. I. Karaeva NANA «Problemy fiziologii i biohimii». 2004 Vol. XXII. P. 284–289.
Osadchaya L. M. Svobodnye aminokisloty nervnoy sistemy. In: Biohimiya mozga. Izd-vo SPb. Un. 1999. P. 29–58.
Palchik A. B., Shabanov N. P. Gipoksicheskiishemicheskaya entsefalopatiya novorozhdennyh: rukovodstvo dlya vrachey. SPb: Piter. 2001. 224 p.
Panahova H. G. Belkovoe golodanie I izofermentnyy spektr laktatdegidrogenazy v golovnom mozge krys. Tr. In-ta Fiziologii im A. I. Karaeva NANA «Problemy fiziologii i biohimii». 2004. Vol. XXII. P. 297–303.
Rashidova A. M., Gabilova L. V., Halilov V. M., Chukmareva V. R. Spetsifichnost proyavleniya aktivnosti fermentov transaminaznoy gruppy v tkanyah struktur golovnogo mozga posle razrusheniya funktsii analizatorov. «Biohimiya segodnya i zavtra», Nauchnoy konferentsiya BGU, Baku. 2003. P. 148–149.
Rashidova A. M. Neorganicheskaya pirofosfataza I realizatsiya energoobspecheniya golovnogo mozga pri belkovom golodanii.Biomeditsina. Baku. 2007a. No 3. P. 13–15.
Rashidova A. M. Vliyanie parov letuchih fraktsiy syroy nefti naaktivnost piruvatkinazy mozga. Tr. In-ta fiziologii im. A. I. Karaeva NANA. Problemy fiziologii i biohimii. Baku. 2007b. Vol. XXV. P. 255–262.
Rashidova A. M., Gashimova U. F. Osobennosti dinamiki aktivnosti piruvat kinazy v tsitozole struktur mozga obluchennyh molodyh i vzroslyh krys. Sb. trudov Mezhdunarodnoy konferentsii «Radioekologiya-2017», Kiev, 25–26 aprelya, 2017. P. 210–213.
Rashidova A. M. Mezhpolusharnoe razlichie aktivnosti piruvat kinazy v tsitozole kory i bolshih polushariy golovnogo mozga belyh krys v ontogeneze na fone vozdeystviya gipoksii. Yubil. nauchnaya konf. «Mozg i neyrotehnologii: ot fundamentalnyh issledovaniy k klinike (k 90-letiyu so dnya osnovaniya Instituta Mozga) 20–21 dekabrya-2018 goda. Asimmetriya, Moskva. 2018. Vol. 12(4). P. 609–610. doi: 10.18454/ASY.2018.12.96.001.
Rashidova A. M. Dinamika soderzhaniy obschego belka v tkanyah struktur mozga krys pri narushenii sensornoy impulsatsii. «Aktualnye problem sovremennoy prirody i ekonomiki», Mezhdunarodnaya nauchnaya konferentsiya, GGU 2–3 maya 2019a, (g.Gyandzha), Azerbaydzhan. P. 268–271.
Rashidova A. M., Gashimova U. F. Vozrastzavisimaya aktivnost laktat degidrogenazy v strukturah golovnogo mozga krys v postnatalnom ontogeneze, gipoksirovannyh v plodnyy period. Evolyutsionnaya biohimiya i fiziologiya, Rossiya, 2019b. Vol. 55(3) P. 172–178.
Rashidova A. M., Gashimova U. F., Kadimova Z. M. Issledovanie aktivnosti fermentov energoobmena i sostoyaniya serdechno-sosudistoy sistemy u lits pozhilogo i starcheskogo vozrasta. Uspehi gerontologii, RF, SPb, 2019. Vol. 32(4). P. 578–586.
Safihanova H. M., Kasimov R. Yu., Rustamov E. K. Vliyanie eksperimentalnogo neftyanogo zagryazneniya na krov sazana. Izvestiya NANA (biologicheskie i meditsinskie nauki). 2014. Vol. 69(1). P. 60–65.
Fokin V. F. i dr. Statsionarnaya i dinamicheskaya organizatsiya funktsionalnoy mezhpolusharnoy asimmetrii. Ruk-vo po funktsionalnoy mezhpolusharnoy asimmetrii., Ch. 14. M., Nauchnyy mir. 2009. P. 389–428.
Haydarliu S. H. Funktsionalnaya biohimiya adaptatsii. Kishinev, Shtiintsa. 1984. 265 p.
Holodov Yu. A. Potok monografiy po elektromagnitobiologii. Magnitobiologiya. 1993. 1 (15). Р. 64–70.
Yashin A. I. Rezonansnye effekty vo vzaimodeystvii elektromagnitnyh poley s biosistemami. ch. I. Vidy rezonansovih i ih fiziko-biologicheskie modeli. Journal of new medical technologies. 2018. No 2. P.127–143. doi: 10.24411/2075-4094-2018-16005.
Bergmeyer H. U. Biochemistry information. Methods of enzymatic analysis, Verlag Chemie, Weinheim. 1975.
Candora S. M., Verni P., Minelly C. M et. al. Occupation risks among public safety and security forces. G. Ital. Lav. Ergo. 2006. Vol. 28(1). P. 53–62.
Chinopoulos C., Zhang S. F., Thomas B., Ten V., Starkov A. A. Isolation and functional assessment of mitochondria from small amounts of mouse brain tissues. Methods Mol Biol. 2011. Vol. 793. P. 311–324.
Darnell J. E. Jr., Kerr J. M., Stark G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994. V. 264. P. 1415-1421.
Grigorev Yu. G., Shafirkin A. V., Vasin A. L. Biological effects of microwave radiation of low no thermal intensity (regarding the maximal admissible values). Aviakosm. Ecology Med. 2005. Vol. 39(4). P. 3–18.
Harman D. Free radical theory of aging: an update increasing the functional life span. Annals of the NY academy of Sciences, 10 may 2006. P. 10–21.
Koshoridze N., Menabde K., Chachua M., Kuchukashvili Z. Enzymes of energy metabolism in brain and chronic stress. Journal of Stress Physiology & Biochemistry. 2009. Vol. 5(1–2). P. 32–37.
Kruger N. J. Bradford method for protein quantitation. The protein Protocols Handbook, (2-nd ed. Ed. be J. M. Walker, Humana press Inc.). 2002. Р. 15–21.
Mekhtiev A. A., Panahova E. N., Rashidova A. M., Guseinov Sh. B. Engagement of serotonin-modulating anticonsolidation protein in memory formation and suppression of drug addiction and epileptic seizures. In: New Developments in Serotonin Research. USA, NY. 2015. Ch. 6. P. 123–143.
Mishra O. P. Delivoria-Papadopoulos M. Cellular mechanisms of hypoxic injury in the developing brain. Brain res. Bull. 1999. V. 48. P. 233–238. doi: 10.1016/s0361-9230(98)00170-1
Pellegrino L. J., Pellegrino A. S., Cusman A. Z. A stereotaxic atlas of the rat brain. Plenum Press. NY. 1979. 123 p.
Pellerin L., Magistretti P. J. Ноw to balance the brain energy budget while spending glucose differently. J. Physiol. 2003. Vol. 546(2). Р. 325.
Rashidova A. M., Guseynova L. M. Impact on pyruvate kinase activity in brain tissues of white rats by decametric electromagnetic irradiation. VI s. Radiobiologicheskogo obshhestva Ukrainy. 2015. P. 111.
Rashidova A. M. Effect of pre-/postnatal hypoxia on pyruvate kinase in rat brain. Int. J. Sec. Metabolite.2018а. Vol. 5(3). P. 224–232. doi: 10.21448/Ijsm.450963.
Rashidova A. M. Lactate dehydrogenase activity in brain structures of white rats in postnatal ontogenesis, exposed to 5 % and 10 % hypoxia at fertilization period. National Journal of Neurology. 2018б. Vol. 2(14). P. 24–29.
Rashidova A. M. Effect of different levels of hypoxia in the fetus period of prenatal development on lactatdehidrogenase and pyruvate kinase activities in brain structures. Tr. Obschestva zoologov Azerbajdzhana. 2018. Vol. 36(1). p. 102–115.
Schmidt W. et al. Ontogenesis of the brain the biochem. funct. struct. dev. of nervous system. Univ. Car. Prag. 1987. Vol. 4. P. 345–349.
Stroyev S. A. et al. Effect of prenatal hypoxia on the expression of thioredoxin-1 in the rat hippocampus at different times. Neurokhimiya. 2011, Vol. 28(3). P. 226–231.
Vega C., Martiel J.-L., Drouhault D., Burckhart M.-F., Coles J. A. Uptake of locally applied deoxyglucose, glucose and lactate by axons and Schwann cells of rat vagus nerve. J. Physiol. 2003. Vol. 546. P. 551–564.
Zosangzuali M. Z., Lalramdinpuii M. & Ganesh Chandra Jagetia. Impact of radiofrequency radiation on DNA damage and antioxidants in peripheral blood lymphocytes of humans residing in the vicinity of mobile phone base stations. Elektromagnetic biology and medicine. 2017. Vol. 36(3), P. 295–305. doi: /10.1080/15368378.2017
