Соматична мутація R248C (742 C>T) гена FGFR3 за раку сечового міхура
Aim. The aim of our study was to determine the frequency of FGFR3 R248C mutation in Ukrainian patients with a bladder cancer. Methods. The mutation was detected by PCR with allele specific primers. We investigated mutation in 90 DNA samples of patients with bladder cancer. Results. The FGFR3 R248C mutation was found in 1 case of urothelial carcinoma. Conclusions. We found 1 mutation in patient with muscle invasive tumor. The prognosis of the patient is generally good.
Keywords: FGFR3, mutation frequency, bladder cancer.