The problem of plants resistance to herbicides – inhibitors of acetolactate synthase

  • Zh. Z. Guralchuk
  • Ye. Yu. Morderer


Aim. The purpose of the work is to analyze the available literature data associated with the emergence of resistance to herbicides ALS inhibitors. Results. Target resistance to herbicides ALS inhibitors is a consequence of genetic mutations due to the replacement of one amino acid with another in the enzyme polypeptide. The article deals with data on the action of herbicides ALS inhibitors on the functioning of the enzyme and its modification in the presence of mutations that predispose the resistance to herbicides ALS inhibitors. Brief description of the structural features of the binding of various classes of herbicides inhibitors ALS with the target enzyme and the modification of the cofactors (thiamine diphosphate and flavin adenine dinucleotide) is presented. Conclusions. Studies of recent decades have led to an increase in knowledge about the action characteristics of herbicides belonging to different classes of ALS inhibitors and the causes of resistance. The obtained results are the basis for better understanding of the mechanisms of resistance to herbicides and the development of ways to overcome them.

Keywords: herbicides, acetolactate synthase, resistance, gene mutation.


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